Tell your doctor or pharmacist right away if you have withdrawal. Withdrawal is more likely if you have used this medication for a long time or in high doses. To help prevent withdrawal, your doctor may lower your dose slowly. If you suddenly stop using this medication, you may have withdrawal symptoms (such as severe tiredness, sleep problems, mental/mood changes such as depression). To help you remember, take it at the same time(s) each day.ĭuring treatment, your doctor may occasionally recommend stopping the medication for a short time to see whether there are any changes in your behavior and whether the medication is still needed. Use this medication regularly to get the most benefit from it. Follow your doctor's instructions carefully. Your doctor may adjust your dose to find the dose that is best for you. The dosage is based on your medical condition and response to treatment. Taking this medication late in the day may cause trouble sleeping ( insomnia). If more doses are prescribed, take them as directed by your doctor, usually 4-6 hours apart. The first dose is usually taken when you wake up in the morning. Take this medication by mouth with or without food as directed by your doctor, usually 1 to 3 times a day. If you have any questions, ask your doctor or pharmacist. This article discusses our present understanding of Adderall ® intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug.Read the Medication Guide provided by your pharmacist before you start taking amphetamine/ dextroamphetamine and each time you get a refill. Differential diagnoses that should be considered in cases of suspected amphetamine overdose are any other agents that can cause central nervous system stimulation, tremors, and seizures. Prognosis after poisoning with Adderall ® depends upon the severity and duration of clinical signs at presentation. Intravenous fluids counter the hyperthermia, assist in maintenance of renal function, and help promote the elimination of amphetamine and its analogues. Cardiac tachyarrhythmias can be managed with a β-blocker such as propranolol. Seizures can be controlled with benzodiazepines, phenothiazines, pentobarbital, and propofol. Treatment is directed at controlling life-threatening central nervous system and cardiovascular signs. Diagnosis can be confirmed by detecting amphetamine in stomach contents or vomitus, or by positive results obtained in urine tests for illicit drugs. In addition, Adderall intoxication in dogs has been reported to cause hyperthermia, hypoglycemia, hypersegmentation of neutrophils, and mild thrombocytopenia. Clinical signs of Adderall ® overdose in humans and dogs include hyperactivity, hyperthermia, tachycardia, tachypnea, mydriasis, tremors, and seizures. β-Adrenergic receptor stimulation leads to an increase in heart rate, stroke volume, and skeletal muscle blood flow. α–Adrenergic stimulation causes vasoconstriction and an increase in total peripheral resistance. Amphetamine and its analogues stimulate the release of norepinephrine affecting both α– and β–adrenergic receptor sites. For humans with ADHD or narcolepsy, standard recommended dosage is 5–60 mg daily. These agents are DEA Schedule II controlled substances with high potential for abuse. These drugs are used off label by college students for memory enhancement, test taking ability, and for study marathons. Knowing the exact agent ingested can provide information of dose labeled and length of clinical effects. Both immediate and sustained release products are used as are single agent amphetamine medication. Adderall ® (amphetamine dextroamphetamine) and a variety of brand names and generic versions of this combination are available by prescription to treat ADHD and narcolepsy. The American Psychiatric Association estimates that 3–7% of US school–aged children exhibit attention-deficit/hyperactivity disorder (ADHD).
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